Assessing the Solubility of Baricitinib and Drug Uptake in Different Tissues Using Absorption and Fluorescence Spectroscopies

• Main Authors: Roya Mohammadi-Meyabadi (Author), Negar Beirampour (Author), Núria Garrós (Author), Helen Lissette Alvarado (Author), David Limón (Author), Marcelle Silva-Abreu (Author), Ana Cristina Calpena (Author), Mireia Mallandrich (Author)
• Format: Book
• Published: MDPI AG, 2022-12-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

The low water solubility of baricitinib (BCT) limits the development of new formulations for the topical delivery of the drug. The aims of this study were to assess the solubility of BCT in different solvents, including Transcutol, a biocompatible permeation enhancer that is miscible in water, to ev...