Investigation of Dissolution Mechanism and Release Kinetics of Poorly Water-Soluble Tadalafil from Amorphous Solid Dispersions Prepared by Various Methods

• मुख्य लेखकों: Tereza Školáková (लेखक), Michaela Slámová (लेखक), Andrea Školáková (लेखक), Alena Kadeřábková (लेखक), Jan Patera (लेखक), Petr Zámostný (लेखक)
• स्वरूप: पुस्तक
• प्रकाशित: MDPI AG, 2019-08-01T00:00:00Z.
• विषय: article
• ऑनलाइन पहुंच: Connect to this object online.

The aims of this study were to investigate how the release of tadalafil is influenced by two grades of polyvinylpyrrolidone (Kollidon^® 12 PF and Kollidon^® VA 64) and various methods of preparing solid dispersions (solvent evaporation, spray drying and ho...