Chrysin serves as a novel inhibitor of DGKα/FAK interaction to suppress the malignancy of esophageal squamous cell carcinoma (ESCC)

• Päätekijät: Jie Chen (Tekijä), Yan Wang (Tekijä), Di Zhao (Tekijä), Lingyuan Zhang (Tekijä), Weimin Zhang (Tekijä), Jiawen Fan (Tekijä), Jinting Li (Tekijä), Qimin Zhan (Tekijä)
• Aineistotyyppi: Kirja
• Julkaistu: Elsevier, 2021-01-01T00:00:00Z.
• Aiheet: article
• Linkit: Connect to this object online.

Among current novel druggable targets, protein-protein interactions (PPIs) are of considerable and growing interest. Diacylglycerol kinase α (DGKα) interacts with focal adhesion kinase (FAK) band 4.1-ezrin-radixin-moesin (FERM) domain to induce the phosphorylation of FAK Tyr397 site and promotes the...