Chrysin serves as a novel inhibitor of DGKα/FAK interaction to suppress the malignancy of esophageal squamous cell carcinoma (ESCC)

• Hoofdauteurs: Jie Chen (Auteur), Yan Wang (Auteur), Di Zhao (Auteur), Lingyuan Zhang (Auteur), Weimin Zhang (Auteur), Jiawen Fan (Auteur), Jinting Li (Auteur), Qimin Zhan (Auteur)
• Formaat: Boek
• Gepubliceerd in: Elsevier, 2021-01-01T00:00:00Z.
• Onderwerpen: article
• Online toegang: Connect to this object online.

Among current novel druggable targets, protein-protein interactions (PPIs) are of considerable and growing interest. Diacylglycerol kinase α (DGKα) interacts with focal adhesion kinase (FAK) band 4.1-ezrin-radixin-moesin (FERM) domain to induce the phosphorylation of FAK Tyr397 site and promotes the...