Evaluation of Transdermal Transport and Concurrent Cutaneous Hydrolysis of Timolol Prodrug for the Treatment of Infantile Hemangiomas

• Main Authors: Shih-Jen Chang (Author), Huiyuan Wang (Author), Jialin Chen (Author), Qianyi Chen (Author), Lei Chang (Author), Yongzhuo Huang (Author), Yajing Qiu (Author), Xiaoxi Lin (Author)
• Format: Book
• Published: MDPI AG, 2022-08-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Infantile hemangiomas (IH) leave sequelae after involution. Topical application of timolol maleate (TM) is the mainstream treatment for superficial lesions but is limited by its low penetrable properties. We aimed to develop a superior skin permeation drug while maintaining the therapeutic propertie...