Elucidating heavy/light chain pairing preferences to facilitate the assembly of bispecific IgG in single cells

• Main Authors: Kamal Kishore Joshi (Author), Wilson Phung (Author), Guanghui Han (Author), Yiyuan Yin (Author), Ingrid Kim (Author), Wendy Sandoval (Author), Paul J. Carter (Author)
• Format: Book
• Published: Taylor & Francis Group, 2019-10-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Multiple strategies have been developed to facilitate the efficient production of bispecific IgG (BsIgG) in single host cells. For example, we previously demonstrated near quantitative (≥90%) formation of BsIgG of different species and isotypes by combining 'knob-into-hole' mutations for h...