Preclinical Safety Profile of an Oral Naringenin/Hesperidin Dosage Form by In Vivo Toxicological Tests

• Main Authors: Carla Georgina Cicero-Sarmiento (Author), Rolffy Ortiz-Andrade (Author), Jesús Alfredo Araujo-León (Author), Maira Rubí Segura-Campos (Author), Priscila Vazquez-Garcia (Author), Héctor Rubio-Zapata (Author), Efrén Hernández-Baltazar (Author), Victor Yañez-Pérez (Author), Amanda Sánchez-Recillas (Author), Juan Carlos Sánchez-Salgado (Author), Emanuel Hernández-Núñez (Author), Durcy Ruiz-Ciau (Author)
• Format: Book
• Published: MDPI AG, 2022-05-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

We developed a naringenin-hesperidin molar mixture (MIX-160) with proven antihyperglycemic and vasorelaxant activity in preclinical studies. A solid dosage form was manufactured to improve the bioavailability properties. In the current study, we sought to evaluate the oral preclinical toxicity of th...