Monitoring the in vivo siRNA release from lipid nanoparticles based on the fluorescence resonance energy transfer principle

• Main Authors: Lei Sun (Author), Jinfang Zhang (Author), Jing-e Zhou (Author), Jing Wang (Author), Zhehao Wang (Author), Shenggen Luo (Author), Yeying Wang (Author), Shulei Zhu (Author), Fan Yang (Author), Jie Tang (Author), Wei Lu (Author), Yiting Wang (Author), Lei Yu (Author), Zhiqiang Yan (Author)
• Format: Book
• Published: Elsevier, 2023-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

The siRNA-loaded lipid nanoparticles have attracted much attention due to its significant gene silencing effect and successful marketization. However, the in vivo distribution and release of siRNA still cannot be effectively monitored. In this study, based on the fluorescence resonance energy transf...