Myocardial chemokine expression and intensity of myocarditis in Chagas cardiomyopathy are controlled by polymorphisms in CXCL9 and CXCL10.

• Main Authors: Luciana Gabriel Nogueira (Author), Ronaldo Honorato Barros Santos (Author), Barbara Maria Ianni (Author), Alfredo Inácio Fiorelli (Author), Eliane Conti Mairena (Author), Luiz Alberto Benvenuti (Author), Amanda Frade (Author), Eduardo Donadi (Author), Fabrício Dias (Author), Bruno Saba (Author), Hui-Tzu Lin Wang (Author), Abilio Fragata (Author), Marcelo Sampaio (Author), Mario Hiroyuki Hirata (Author), Paula Buck (Author), Charles Mady (Author), Edimar Alcides Bocchi (Author), Noedir Antonio Stolf (Author), Jorge Kalil (Author), Edecio Cunha-Neto (Author)
• Format: Book
• Published: Public Library of Science (PLoS), 2012-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

BACKGROUND: Chronic Chagas cardiomyopathy (CCC), a life-threatening inflammatory dilated cardiomyopathy, affects 30% of the approximately 8 million patients infected by Trypanosoma cruzi. Even though the Th1 T cell-rich myocarditis plays a pivotal role in CCC pathogenesis, little is known about the...