Agonist and antagonist effects of tobacco-related nitrosamines on human α4β2 nicotinic acetylcholine receptors.

Agonist and antagonist effects of tobacco-related nitrosamines on human α4β2 nicotinic acetylcholine receptors.

Regulation of the 'neuronal' nicotinic acetylcholine receptors (nAChRs) is implicated in both tobacco addiction and smoking-dependent tumor promotion. Some of these effects are caused by the tobacco-derived N-nitrosamines, which are carcinogenic compounds that avidly bind to nAChRs. Howeve...

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Main Authors: Simone eBrusco (Author), Paola eAmbrosi (Author), Simone eMeneghini (Author), Andrea eBecchetti (Author)
Format: Book
Published: Frontiers Media S.A., 2015-09-01T00:00:00Z.
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3rd Floor Main Library

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