Thrombin Induces COX-2 and PGE2 Expression via PAR1/PKCalpha/MAPK-Dependent NF-kappaB Activation in Human Tracheal Smooth Muscle Cells

• Main Authors: Chien-Chung Yang (Author), Li-Der Hsiao (Author), Ya-Fang Shih (Author), Chih-Kai Hsu (Author), Chia-Yu Hu (Author), Chuen-Mao Yang (Author)
• 格式: 圖書
• 出版: Hindawi Limited, 2022-01-01T00:00:00Z.
• 主題: article
• 在線閱讀: Connect to this object online.

The inflammation of the airway and lung could be triggered by upregulation cyclooxygenase (COX)-2 and prostaglandin E2 (PGE2) induced by various proinflammatory factors. COX-2 induction by thrombin has been shown to play a vital role in various inflammatory diseases. However, in human tracheal smoot...