Novel opioid-neurotensin-based hybrid peptide with spinal long-lasting antinociceptive activity and a propensity to delay tolerance development

• Main Authors: Karolina Frączek (Author), Mattia Ferraiolo (Author), Emmanuel Hermans (Author), Magdalena Bujalska-Zadrozny (Author), Kaja Kasarello (Author), Anna Erdei (Author), Kamila Kulik (Author), Agnieszka Kowalczyk (Author), Piotr Wojciechowski (Author), Dorota Sulejczak (Author), Piotr Sosnowski (Author), Sebastian Granica (Author), Sandor Benyhe (Author), Katarzyna Kaczynska (Author), Lukasz Nagraba (Author), Artur Stolarczyk (Author), Agnieszka Cudnoch-Jedrzejewska (Author), Patrycja Kleczkowska (Author)
• Format: Book
• Published: Elsevier, 2020-08-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

The behavioral responses exerted by spinal administration of the opioid-neurotensin hybrid peptide, PK23, were studied in adult male rats. The antinociceptive effect upon exposure to a thermal stimulus, as well as tolerance development, was assessed in an acute pain model. The PK23 chimera at a dose...