Novel opioid-neurotensin-based hybrid peptide with spinal long-lasting antinociceptive activity and a propensity to delay tolerance development
The behavioral responses exerted by spinal administration of the opioid-neurotensin hybrid peptide, PK23, were studied in adult male rats. The antinociceptive effect upon exposure to a thermal stimulus, as well as tolerance development, was assessed in an acute pain model. The PK23 chimera at a dose...
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Formaat: | Boek |
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Elsevier,
2020-08-01T00:00:00Z.
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Internet
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A1234.567 |
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Kopie 1 | Beschikbaar |