Upregulation of Phosphodiesterase 2A Augments T Cell Activation by Changing cGMP/cAMP Cross-Talk

• Main Authors: Roberta Kurelic (Author), Paula F. Krieg (Author), Jana K. Sonner (Author), Gloria Bhaiyan (Author), Gustavo C. Ramos (Author), Stefan Frantz (Author), Manuel A. Friese (Author), Viacheslav O. Nikolaev (Author)
• Format: Book
• Published: Frontiers Media S.A., 2021-10-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

3',5'-cyclic adenosine monophosphate (cAMP) is well-known for its diverse immunomodulatory properties, primarily inhibitory effects during T cell activation, proliferation, and production of pro-inflammatory cytokines. A decrease in cAMP levels, due to the hydrolyzing activity of phosphodi...