Design, synthesis and in vitro and in vivo biological evaluation of flurbiprofen amides as new fatty acid amide hydrolase/cyclooxygenase-2 dual inhibitory potential analgesic agents

• Main Authors: Alessandro Deplano (Author), Jessica Karlsson (Author), Federica Moraca (Author), Mona Svensson (Author), Claudia Cristiano (Author), Carmine Marco Morgillo (Author), Christopher J. Fowler (Author), Roberto Russo (Author), Bruno Catalanotti (Author), Valentina Onnis (Author)
• Format: Book
• Published: Taylor & Francis Group, 2021-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Compounds combining dual inhibitory action against FAAH and cyclooxygenase (COX) may be potentially useful analgesics. Here, we describe a novel flurbiprofen analogue, N-(3-bromopyridin-2-yl)-2-(2-fluoro-(1,1'-biphenyl)-4-yl)propanamide (Flu-AM4). The compound is a competitive, reversible inhib...