Role of Glycogen Synthase Kinase-3β in APP Hyperphosphorylation Induced by NMDA Stimulation in Cortical Neurons

Role of Glycogen Synthase Kinase-3β in APP Hyperphosphorylation Induced by NMDA Stimulation in Cortical Neurons

The phosphorylation of Amyloid Precursor Protein (APP) at Thr668 plays a key role in APP metabolism that is highly relevant to AD. The c-Jun-N-terminal kinase (JNK), glycogen synthase kinase-3β (GSK-3β) and cyclin-dependent kinase 5 (Cdk5) can all be responsible for this phosphorylation. These kinas...

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Main Authors: Xanthi Antoniou (Author), Gianluigi Forloni (Author), Monica Di Luca (Author), Fabrizio Gardoni (Author), Mariaelena Repici (Author), Alessio Colombo (Author), Alessandra Sclip (Author), Cristina Ploia (Author), Tiziana Borsello (Author)
Format: Book
Published: MDPI AG, 2010-01-01T00:00:00Z.
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3rd Floor Main Library

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Call Number: A1234.567
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