Functionalized lipid nanoparticles modulate the blood-brain barrier and eliminate α-synuclein to repair dopamine neurons

• Κύριοι συγγραφείς: Xiaomei Wu (Συγγραφέας), Renxiang Yuan (Συγγραφέας), Yichong Xu (Συγγραφέας), Kai Wang (Συγγραφέας), Hong Yuan (Συγγραφέας), Tingting Meng (Συγγραφέας), Fuqiang Hu (Συγγραφέας)
• Μορφή: Βιβλίο
• Έκδοση: Elsevier, 2024-04-01T00:00:00Z.
• Θέματα: article
• Διαθέσιμο Online: Connect to this object online.

The challenge in the clinical treatment of Parkinson's disease lies in the lack of disease-modifying therapies that can halt or slow down the progression. Peptide drugs, such as exenatide (Exe), with potential disease-modifying efficacy, have difficulty in crossing the blood-brain barrier (BBB)...