Chitosan-Hyaluronan Nanoparticles for Vinblastine Sulfate Delivery: Characterization and Internalization Studies on K-562 Cells

• Main Authors: Carmela Cannavà (Author), Federica De Gaetano (Author), Rosanna Stancanelli (Author), Valentina Venuti (Author), Giuseppe Paladini (Author), Francesco Caridi (Author), Corneliu Ghica (Author), Vincenza Crupi (Author), Domenico Majolino (Author), Guido Ferlazzo (Author), Silvana Tommasini (Author), Cinzia Anna Ventura (Author)
• Format: Book
• Published: MDPI AG, 2022-04-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

In the present study, we developed chitosan/hyaluronan nanoparticles (CS/HY NPs) for tumor targeting with vinblastine sulfate (VBL), that can be directed to the CD44 transmembrane receptor, over-expressed in cancer cells. NPs were prepared by coating with HY-preformed chitosan/tripolyphosphate (CS/T...