Sex-Dependence in the Effect of Pharmaceutical Excipients: Polyoxyethylated Solubilising Excipients Increase Oral Drug Bioavailability in Male but not Female Rats

• Main Authors: Yang Mai (Author), Liu Dou (Author), Christine M. Madla (Author), Sudaxshina Murdan (Author), Abdul W. Basit (Author)
• Formato: Libro
• Publicado: MDPI AG, 2019-05-01T00:00:00Z.
• Subjects: article
• Acceso en liña: Connect to this object online.

It is known that males and females respond differently to medicines and that differences in drug behaviour are due to inter-individual variability and sex specificity. In this work, we have examined the influence of pharmaceutical excipients on drug bioavailability in males and females. Using a rat...