Novel Mechanism for an Old Drug: Phenazopyridine is a Kinase Inhibitor Affecting Autophagy and Cellular Differentiation

• Main Authors: Olivier Preynat-Seauve (Author), Evelyne Bao-Vi Nguyen (Author), Yvonne Westermaier (Author), Margaux Héritier (Author), Sébastien Tardy (Author), Yves Cambet (Author), Maxime Feyeux (Author), Aurélie Caillon (Author), Leonardo Scapozza (Author), Karl-Heinz Krause (Author)
• Format: Book
• Published: Frontiers Media S.A., 2021-08-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Phenazopyridine is a widely used drug against urinary tract pain. The compound has also been shown to enhance neural differentiation of pluripotent stem cells. However, its mechanism of action is not understood. Based on its chemical structure, we hypothesized that phenazopyridine could be a kinase...