Quantification of mitochondrial DNA damage and copy number in circulating blood of patients with systemic sclerosis by a qPCR-based assay,

• Main Authors: Shafieh Movassaghi (Author), Sara Jafari (Author), Kowsar Falahati (Author), Mitra Ataei (Author), Mohammad Hossein Sanati (Author), Zohreh Jadali (Author)
• Format: Book
• Published: Sociedade Brasileira de Dermatologia, 2020-07-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Abstract Background: Although not fully understood, oxidative stress has been implicated in the pathogenesis of different autoimmune diseases such as systemic sclerosis. Accumulating evidence indicates that oxidative stress can induce mitochondrial DNA (mtDNA) damage and variations in mtDNA copy num...