Creatinine Trends to Detect Ibuprofen-Related Maturational Adverse Drug Events in Neonatal Life: A Simulation Study for the ELBW Newborn

• Main Authors: Tamara van Donge (Author), Karel Allegaert (Author), Marc Pfister (Author), Anne Smits (Author), John van den Anker (Author)
• Formato: Libro
• Publicado: Frontiers Media S.A., 2021-01-01T00:00:00Z.
• Subjects: article
• Acceso en liña: Connect to this object online.

Background: Recognizing a change in serum creatinine concentrations is useful to detect a renal adverse drug reaction signal. Assessing and characterizing the nephrotoxic side-effects of drugs in extremely low birth weight (ELBW, ≤1000 g) neonates remain challenging due to the high variability in cr...