Proteolytic and Non-proteolytic Activation of Keratinocyte-Derived Latent TGF-β1 Induces Fibroblast Differentiation in a Wound-Healing Model Using Rat Skin

• 主要な著者: Shozaburo Hata (著者), Kazuhiko Okamura (著者), Mitsutoki Hatta (著者), Hiroyuki Ishikawa (著者), Jun Yamazaki (著者)
• フォーマット: 図書
• 出版事項: Elsevier, 2014-01-01T00:00:00Z.
• 主題: article
• オンライン･アクセス: Connect to this object online.

Transforming growth factor-β1 (TGF-β1) reportedly causes the differentiation of fibroblasts to myofibroblasts during wound healing. We investigated the mechanism underlying the activation of latent TGF-β1 released by keratinocytes in efforts to identify promising pharmacological approaches for the p...