Inhibitory Activity of Andrographolide and Andrograpanin on the Rate of PGH2 Formation

• Main Authors: Sri A. Sumiwi (Author), Eli Halimah (Author), Nyi M. Saptarini (Author), Jutti Levita (Author), As'ari Nawawi (Author), Abdul Mutalib (Author), Slamet Ibrahim (Author)
• Format: Book
• Published: Universitas Padjadjaran, 2016-12-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Cyclooxygenase (COX) or prostaglandin H2 synthase (PGHS) catalyzes the conversion of arachidonic acid into prostaglandins. Nonsteroidal anti-inflammatory drugs (NSAIDs) work by inhibiting both COX-1 and COX-2 isoforms, thus disturbing this reaction. In Indonesia, Andrographis paniculata (local name:...