High OCT4 and Low p16INK4A Expressions Determine In Vitro Lifespan of Mesenchymal Stem Cells

• 主要な著者: Carla A. Piccinato (著者), Andrea L. Sertie (著者), Natália Torres (著者), Mario Ferretti (著者), Eliane Antonioli (著者)
• フォーマット: 図書
• 出版事項: Hindawi Limited, 2015-01-01T00:00:00Z.
• 主題: article
• オンライン･アクセス: Connect to this object online.

After long-term culture, mesenchymal stem cells alter their biological properties and enter into a state of replicative senescence. Although several classical biomarkers have been used for quantitative assessment of cellular senescence, no hallmark has been proven completely unique to the senescent...