Layer-by-layer pH-sensitive nanoparticles for drug delivery and controlled release with improved therapeutic efficacy in vivo

• Main Authors: Wanfu Men (Author), Peiyao Zhu (Author), Siyuan Dong (Author), Wenke Liu (Author), Kun Zhou (Author), Yu Bai (Author), Xiangli Liu (Author), Shulei Gong (Author), Shuguang Zhang (Author)
• Format: Book
• Published: Taylor & Francis Group, 2020-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

In this work, a pH-sensitive liposome-polymer nanoparticle (NP) composed of lipid, hyaluronic acid (HA) and poly(β-amino ester) (PBAE) was prepared using layer-by-layer (LbL) method for doxorubicin (DOX) targeted delivery and controlled release to enhance the cancer treatment efficacy. The NP with p...