Pimaric acid reduces vasoconstriction via BKCa channel activation and VDCC inhibition in rat pulmonary arterial smooth muscles

• Main Authors: Masashi Ishida (Author), Aya Yamamura (Author), Moe Fujiwara (Author), Taiki Amano (Author), Mina Ota (Author), Yukari Hikawa (Author), Rubii Kondo (Author), Yoshiaki Suzuki (Author), Yuji Imaizumi (Author), Hisao Yamamura (Author)
• Format: Book
• Published: Elsevier, 2023-10-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Pulmonary vessels play a pivotal role in oxygen circulation. We previously demonstrated that pimaric acid (PiMA) activated large-conductance Ca2+-activated K+ (BKCa) channels and inhibited voltage-dependent Ca2+ channels (VDCCs). In the present study, PiMA attenuated vasoconstriction induced by high...