Differential Impact of LPG-and PG-Deficient Leishmania major Mutants on the Immune Response of Human Dendritic Cells.

• Main Authors: Michelle A Favila (Author), Nicholas S Geraci (Author), Asha Jayakumar (Author), Suzanne Hickerson (Author), Janet Mostrom (Author), Salvatore J Turco (Author), Stephen M Beverley (Author), Mary Ann McDowell (Author)
• Format: Book
• Published: Public Library of Science (PLoS), 2015-12-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

BACKGROUND:Leishmania major infection induces robust interleukin-12 (IL12) production in human dendritic cells (hDC), ultimately resulting in Th1-mediated immunity and clinical resolution. The surface of Leishmania parasites is covered in a dense glycocalyx consisting of primarily lipophosphoglycan...