Differential Impact of LPG-and PG-Deficient Leishmania major Mutants on the Immune Response of Human Dendritic Cells.

• Главные авторы: Michelle A Favila (Автор), Nicholas S Geraci (Автор), Asha Jayakumar (Автор), Suzanne Hickerson (Автор), Janet Mostrom (Автор), Salvatore J Turco (Автор), Stephen M Beverley (Автор), Mary Ann McDowell (Автор)
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• Опубликовано: Public Library of Science (PLoS), 2015-12-01T00:00:00Z.
• Предметы: article
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BACKGROUND:Leishmania major infection induces robust interleukin-12 (IL12) production in human dendritic cells (hDC), ultimately resulting in Th1-mediated immunity and clinical resolution. The surface of Leishmania parasites is covered in a dense glycocalyx consisting of primarily lipophosphoglycan...