Experimental and computational study on anti-gastric cancer activity and mechanism of evodiamine derivatives

• Main Authors: Jingli Liu (Author), Yingying Xue (Author), Kaidi Bai (Author), Fei Yan (Author), Xu Long (Author), Hui Guo (Author), Hao Yan (Author), Guozheng Huang (Author), Jing Zhou (Author), Yuping Tang (Author)
• Format: Book
• Published: Frontiers Media S.A., 2024-05-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Introduction: Human topoisomerase 1 (TOP1) is an important target of various anticancer compounds. The design and discovery of inhibitors targeting TOP1 are of great significance for the development of anticancer drugs. Evodiamine and thieno [2,3-d] pyridine hybrids show potential antitumor activity...