Experimental and computational study on anti-gastric cancer activity and mechanism of evodiamine derivatives

• Autori principali: Jingli Liu (Autore), Yingying Xue (Autore), Kaidi Bai (Autore), Fei Yan (Autore), Xu Long (Autore), Hui Guo (Autore), Hao Yan (Autore), Guozheng Huang (Autore), Jing Zhou (Autore), Yuping Tang (Autore)
• Natura: Libro
• Pubblicazione: Frontiers Media S.A., 2024-05-01T00:00:00Z.
• Soggetti: article
• Accesso online: Connect to this object online.

Introduction: Human topoisomerase 1 (TOP1) is an important target of various anticancer compounds. The design and discovery of inhibitors targeting TOP1 are of great significance for the development of anticancer drugs. Evodiamine and thieno [2,3-d] pyridine hybrids show potential antitumor activity...