Pharmacological Inhibition of STAT3 by Stattic Ameliorates Clinical Symptoms and Reduces Autoinflammation in Myeloid, Lymphoid, and Neuronal Tissue Compartments in Relapsing-Remitting Model of Experimental Autoimmune Encephalomyelitis in SJL/J Mice

• Main Authors: Khalid Alhazzani (Author), Sheikh F. Ahmad (Author), Naif O. Al-Harbi (Author), Sabry M. Attia (Author), Saleh A. Bakheet (Author), Wedad Sarawi (Author), Saleh A. Alqarni (Author), Mohammad Algahtani (Author), Ahmed Nadeem (Author)
• Format: Book
• Published: MDPI AG, 2021-06-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Multiple sclerosis (MS) is an immune-mediated inflammatory disease that leads to demyelination and neuronal loss in the central nervous system. Immune cells of lymphoid and myeloid origin play a significant role in the initiation and amplification of neuronal inflammation in MS. STAT3 signaling play...