Burst-Like Subcutaneous Electrical Stimulation Induces BDNF-Mediated, Cyclotraxin B-Sensitive Central Sensitization in Rat Spinal Cord

• Main Authors: Jeffri Retamal (Author), Andrea Reyes (Author), Paulina Ramirez (Author), David Bravo (Author), Alejandro Hernandez (Author), Teresa Pelissier (Author), Luis Villanueva (Author), Luis Constandil (Author)
• Format: Book
• Published: Frontiers Media S.A., 2018-10-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Intrathecal administration of brain derived neurotrophic factor (BDNF) induces long-term potentiation (LTP) and generates long-lasting central sensitization in spinal cord thus mimicking chronic pain, but the relevance of these observations to chronic pain mechanisms is uncertain. Since C-fiber acti...