Administration of SB239063 Ameliorates Ovariectomy-Induced Bone Loss via Suppressing Osteoclastogenesis in Mice

• Main Authors: Bao Huang (Author), Jiasheng Wang (Author), Xuyang Zhang (Author), Ziang Xie (Author), Hao Wu (Author), Junhui Liu (Author), Zhiwei Jie (Author), Xiangde Zhao (Author), An Qin (Author), Shunwu Fan (Author), Jian Chen (Author), Fengdong Zhao (Author)
• Format: Book
• Published: Frontiers Media S.A., 2019-08-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Activation of osteoclast formation and function is crucial for the development of osteolytic diseases such as osteoporosis. RANKL (receptor activator of nuclear factor-κB ligand) activates NF-κB (nuclear factor κB), MAPK (mitogen-activated protein kinase), and NFATc1 (nuclear factor of activated T-c...