Administration of SB239063 Ameliorates Ovariectomy-Induced Bone Loss via Suppressing Osteoclastogenesis in Mice

• मुख्य लेखकों: Bao Huang (लेखक), Jiasheng Wang (लेखक), Xuyang Zhang (लेखक), Ziang Xie (लेखक), Hao Wu (लेखक), Junhui Liu (लेखक), Zhiwei Jie (लेखक), Xiangde Zhao (लेखक), An Qin (लेखक), Shunwu Fan (लेखक), Jian Chen (लेखक), Fengdong Zhao (लेखक)
• स्वरूप: पुस्तक
• प्रकाशित: Frontiers Media S.A., 2019-08-01T00:00:00Z.
• विषय: article
• ऑनलाइन पहुंच: Connect to this object online.

Activation of osteoclast formation and function is crucial for the development of osteolytic diseases such as osteoporosis. RANKL (receptor activator of nuclear factor-κB ligand) activates NF-κB (nuclear factor κB), MAPK (mitogen-activated protein kinase), and NFATc1 (nuclear factor of activated T-c...