Losartan Protects the Heart Against Ischemia Reperfusion Injury: Sirtuin3 Involvement

• Main Authors: Mohsen Sharifi Klishadi (Author), Farideh Zarei (Author), Seyyed Hassan Hejazian (Author), Ali Moradi (Author), Mahdieh Hemati (Author), Fatemeh Safari (Author)
• Format: Book
• Published: Frontiers Media S.A., 2015-04-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

PURPOSE: Sirtuin-3 (SIRT3) deacetylase protects the heart against oxidative stress via survival factors upregulation. Clinical and experimental studies have demonstrated that activation of systemic and local renin-angiotensin system (RAS) is implicated in ischemia-induced cardiac injury. However, th...