Multivalent IgM scaffold enhances the therapeutic potential of variant-agnostic ACE2 decoys against SARS-CoV-2

• Hlavní autoři: Meghan M. Verstraete (Autor), Florian Heinkel (Autor), Janessa Li (Autor), Siran Cao (Autor), Anh Tran (Autor), Elizabeth C. Halverson (Autor), Robert Gene (Autor), Elizabeth Stangle (Autor), Begonia Silva-Moreno (Autor), Sifa Arrafi (Autor), Jegarubee Bavananthasivam (Autor), Madeline Fung (Autor), Mariam Eji-Lasisi (Autor), Stephanie Masterman (Autor), Steve Xanthoudakis (Autor), Surjit Dixit (Autor), John Babcook (Autor), Brandon Clavette (Autor), Mark Fogg (Autor), Eric Escobar-Cabrera (Autor)
• Médium: Kniha
• Vydáno: Taylor & Francis Group, 2023-12-01T00:00:00Z.
• Témata: article
• On-line přístup: Connect to this object online.

ABSTRACTAs immunological selection for escape mutants continues to give rise to future SARS-CoV-2 variants, novel universal therapeutic strategies against ACE2-dependent viruses are needed. Here we present an IgM-based decavalent ACE2 decoy that has variant-agnostic efficacy. In immuno-, pseudovirus...