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Multivalent IgM scaffold enhances the therapeutic potential of variant-agnostic ACE2 decoys against SARS-CoV-2

ABSTRACTAs immunological selection for escape mutants continues to give rise to future SARS-CoV-2 variants, novel universal therapeutic strategies against ACE2-dependent viruses are needed. Here we present an IgM-based decavalent ACE2 decoy that has variant-agnostic efficacy. In immuno-, pseudovirus...

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Main Authors: Meghan M. Verstraete (Author), Florian Heinkel (Author), Janessa Li (Author), Siran Cao (Author), Anh Tran (Author), Elizabeth C. Halverson (Author), Robert Gene (Author), Elizabeth Stangle (Author), Begonia Silva-Moreno (Author), Sifa Arrafi (Author), Jegarubee Bavananthasivam (Author), Madeline Fung (Author), Mariam Eji-Lasisi (Author), Stephanie Masterman (Author), Steve Xanthoudakis (Author), Surjit Dixit (Author), John Babcook (Author), Brandon Clavette (Author), Mark Fogg (Author), Eric Escobar-Cabrera (Author)
Format: Book
Published: Taylor & Francis Group, 2023-12-01T00:00:00Z.
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