Formyl Peptide Receptor 2-Dependent cPLA2 and 5-LOX Activation Requires a Functional NADPH Oxidase

• Main Authors: Tiziana Pecchillo Cimmino (Author), Iolanda Panico (Author), Simona Scarano (Author), Mariano Stornaiuolo (Author), Gabriella Esposito (Author), Rosario Ammendola (Author), Fabio Cattaneo (Author)
• Format: Book
• Published: MDPI AG, 2024-02-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Phospholipases (PL) A₂ catalyzes the hydrolysis of membrane phospholipids and mostly generates arachidonic acid (AA). The enzyme 5-lipoxygenase (5-LOX) can metabolize AA to obtain inflammatory leukotrienes, whose biosynthesis highly depends on cPLA2 and 5-LOX activities. Formy...