Formyl Peptide Receptor 2-Dependent cPLA2 and 5-LOX Activation Requires a Functional NADPH Oxidase

• Prif Awduron: Tiziana Pecchillo Cimmino (Awdur), Iolanda Panico (Awdur), Simona Scarano (Awdur), Mariano Stornaiuolo (Awdur), Gabriella Esposito (Awdur), Rosario Ammendola (Awdur), Fabio Cattaneo (Awdur)
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• Cyhoeddwyd: MDPI AG, 2024-02-01T00:00:00Z.
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Phospholipases (PL) A₂ catalyzes the hydrolysis of membrane phospholipids and mostly generates arachidonic acid (AA). The enzyme 5-lipoxygenase (5-LOX) can metabolize AA to obtain inflammatory leukotrienes, whose biosynthesis highly depends on cPLA2 and 5-LOX activities. Formy...