Investigation of METTL3 as an inhibitor of kanamycin-induced ototoxicity via stress granule formation

BackgroundMethyltransferase-like 3 (METTL3), a component of the N6-methyladenosine (m6A) methyltransferase family, exhibits significant expression in HEI-OC1 cells and cochlear explants. Aminoglycoside antibiotics, known for their ototoxic potential, frequently induce irreversible auditory damage in...

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Main Authors: Yan Wu (Author), Yu-Yu Huang (Author), Lu-Yao Wang (Author), Yan Yang (Author), Fei-Lun Cui (Author), Shu-Na Li (Author)
Format: Book
Published: Frontiers Media S.A., 2024-08-01T00:00:00Z.
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