Xanthine Oxidase Inhibitor, Febuxostat Is Effective against 5-Fluorouracil-Induced Parotid Salivary Gland Injury in Rats Via Inhibition of Oxidative Stress, Inflammation and Targeting TRPC1/CHOP Signalling Pathway

• मुख्य लेखकों: Walaa Yehia Abdelzaher (लेखक), Mohamed A. Nassan (लेखक), Sabreen Mahmoud Ahmed (लेखक), Nermeen N. Welson (लेखक), Gaber El-Saber Batiha (लेखक), Hanaa Mohamed Khalaf (लेखक)
• स्वरूप: पुस्तक
• प्रकाशित: MDPI AG, 2022-02-01T00:00:00Z.
• विषय: article
• ऑनलाइन पहुंच: Connect to this object online.

The current research aimed to examine the ameliorative role of febuxostat (FEB), a highly potent xanthine oxidase inhibitor, against 5-fluorouracil (5-FU)-induced parotid salivary gland damage in rats, as FEB is a pleiotropic drug that has multiple pharmacological effects. A total of 32 Wistar adult...