Xanthine Oxidase Inhibitor, Febuxostat Is Effective against 5-Fluorouracil-Induced Parotid Salivary Gland Injury in Rats Via Inhibition of Oxidative Stress, Inflammation and Targeting TRPC1/CHOP Signalling Pathway

• Главные авторы: Walaa Yehia Abdelzaher (Автор), Mohamed A. Nassan (Автор), Sabreen Mahmoud Ahmed (Автор), Nermeen N. Welson (Автор), Gaber El-Saber Batiha (Автор), Hanaa Mohamed Khalaf (Автор)
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• Опубликовано: MDPI AG, 2022-02-01T00:00:00Z.
• Предметы: article
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The current research aimed to examine the ameliorative role of febuxostat (FEB), a highly potent xanthine oxidase inhibitor, against 5-fluorouracil (5-FU)-induced parotid salivary gland damage in rats, as FEB is a pleiotropic drug that has multiple pharmacological effects. A total of 32 Wistar adult...