Descending serotonergic facilitation and the antinociceptive effects of pregabalin in a rat model of osteoarthritic pain

• Main Authors: Dolphin Annette C (Author), Vonsy Jean-Laurent (Author), Bannister Kirsty (Author), Bauer Claudia S (Author), Rahman Wahida (Author), Dickenson Anthony H (Author)
• Format: Book
• Published: SAGE Publishing, 2009-08-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

<p>Abstract</p> <p>Background</p> <p>Descending facilitation, from the brainstem, promotes spinal neuronal hyperexcitability and behavioural hypersensitivity in many chronic pain states. We have previously demonstrated enhanced descending facilitation onto dorsal horn n...