Development and Validation of a HPLC-MS/MS Method to Measure Nifuroxazide and Its Application in Healthy and Glioblastoma-Bearing Mice

• Main Authors: Tommaso Ceruti (Author), Quintino Giorgio D'Alessandris (Author), Roberta Frapolli (Author), Jay Gopalakrishnan (Author), Mariachiara Buccarelli (Author), Marina Meroni (Author), Liverana Lauretti (Author), Lucia Ricci-Vitiani (Author), Roberto Pallini (Author), Massimo Zucchetti (Author)
• Format: Book
• Published: MDPI AG, 2022-09-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Nifuroxazide (NAZ), a nitrofuran derivative used to treat diarrhea, has been recently shown to possess anticancer activity. However, its pharmacokinetic profile is poorly known. The pharmacokinetic profile of NAZ was thus investigated in mice using a newly developed method based on high-performance...