CHIR99021 Maintenance of the Cell Stemness by Regulating Cellular Iron Metabolism

• Main Authors: Yingying Han (Author), Yong He (Author), Xiaofang Jin (Author), Jiayi Xie (Author), Peng Yu (Author), Guofen Gao (Author), Shiyang Chang (Author), Jianhua Zhang (Author), Yan-Zhong Chang (Author)
• Format: Book
• Published: MDPI AG, 2023-02-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

CHIR99021 is an aminopyrimidine derivative, which can efficiently inhibit the activity of glycogen synthesis kinase 3α (GSK-3α) and GSK-3β. As an essential component of stem cell culture medium, it plays an important role in maintaining cell stemness. However, the mechanism of its role is not fully...