Targeting Histone Deacetylases in Myeloid Cells Inhibits Their Maturation and Inflammatory Function With Limited Effects on Atherosclerosis

• Main Authors: Rosario Luque-Martin (Author), Jan Van den Bossche (Author), Rebecca C. Furze (Author), Annette E. Neele (Author), Saskia van der Velden (Author), Marion J.J. Gijbels (Author), Cindy P.P.A. van Roomen (Author), Sharon G. Bernard (Author), Wouter J. de Jonge (Author), Inmaculada Rioja (Author), Rab K. Prinjha (Author), Huw D. Lewis (Author), Palwinder K. Mander (Author), Menno P.J. de Winther (Author)
• Format: Book
• Published: Frontiers Media S.A., 2019-10-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Monocytes and macrophages are key drivers in the pathogenesis of inflammatory diseases. Epigenetic targets have been shown to control the transcriptional profile and phenotype of these cells. Since histone deacetylase protein inhibitors demonstrate profound anti-inflammatory activity, we wanted to t...