Targeting Histone Deacetylases in Myeloid Cells Inhibits Their Maturation and Inflammatory Function With Limited Effects on Atherosclerosis

• Автори: Rosario Luque-Martin (Автор), Jan Van den Bossche (Автор), Rebecca C. Furze (Автор), Annette E. Neele (Автор), Saskia van der Velden (Автор), Marion J.J. Gijbels (Автор), Cindy P.P.A. van Roomen (Автор), Sharon G. Bernard (Автор), Wouter J. de Jonge (Автор), Inmaculada Rioja (Автор), Rab K. Prinjha (Автор), Huw D. Lewis (Автор), Palwinder K. Mander (Автор), Menno P.J. de Winther (Автор)
• Формат: Книга
• Опубліковано: Frontiers Media S.A., 2019-10-01T00:00:00Z.
• Предмети: article
• Онлайн доступ: Connect to this object online.

Monocytes and macrophages are key drivers in the pathogenesis of inflammatory diseases. Epigenetic targets have been shown to control the transcriptional profile and phenotype of these cells. Since histone deacetylase protein inhibitors demonstrate profound anti-inflammatory activity, we wanted to t...