Baricitinib counteracts metaflammation, thus protecting against diet-induced metabolic abnormalities in mice

• Main Authors: Debora Collotta (Author), William Hull (Author), Raffaella Mastrocola (Author), Fausto Chiazza (Author), Alessia Sofia Cento (Author), Catherine Murphy (Author), Roberta Verta (Author), Gustavo Ferreira Alves (Author), Giulia Gaudioso (Author), Francesca Fava (Author), Magdi Yaqoob (Author), Manuela Aragno (Author), Kieran Tuohy (Author), Christoph Thiemermann (Author), Massimo Collino (Author)
• Format: Book
• Published: Elsevier, 2020-09-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Objective: Recent evidence suggests the substantial pathogenic role of the Janus kinase (JAK)/signal transducer and activator of transcription (STAT) pathway in the development of low-grade chronic inflammatory response, known as "metaflammation," which contributes to obesity and type 2 di...