Safety and nonclinical and clinical pharmacokinetics of PC945, a novel inhaled triazole antifungal agent

• Main Authors: Lindsey Cass (Author), Alison Murray (Author), Amanda Davis (Author), Kathy Woodward (Author), Muna Albayaty (Author), Kazuhiro Ito (Author), Pete Strong (Author), John Ayrton (Author), Charlie Brindley (Author), Jayne Prosser (Author), John Murray (Author), Eddie French (Author), Phillip Haywood (Author), Christopher Wallis (Author), Garth Rapeport (Author)
• Format: Book
• Published: Wiley, 2021-02-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Abstract PC945 is a novel antifungal triazole formulated for nebulized delivery to treat lung Aspergillus infections. Pharmacokinetic and safety profiles from nonclinical studies and clinical trials in healthy subjects, and subjects with mild asthma were characterized. Toxicokinetics were assessed f...