Antivasospastic Effects of Hydroxyfasudil, a Rho-Kinase Inhibitor, After Subarachnoid Hemorrhage

• Main Authors: Shin-ichi Satoh (Author), Masakazu Takayasu (Author), Koh Kawasaki (Author), Ichiro Ikegaki (Author), Asako Hitomi (Author), Kazuo Yano (Author), Masato Shibuya (Author), Toshio Asano (Author)
• Format: Book
• Published: Elsevier, 2012-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

We investigated the anti-vasospastic potential of fasudil's active metabolite, hydroxyfasudil, a Rho-kinase inhibitor, after subarachnoid hemorrhage (SAH) and also its effect on hemorheological abnormalities following cerebral ischemia. Chronic cerebral vasospasm was produced using a two-hemorr...