Activation of EP4 alleviates AKI-to-CKD transition through inducing CPT2-mediated lipophagy in renal macrophages

• Main Authors: Xu Guan (Author), Yong Liu (Author), Wang Xin (Author), Shaozong Qin (Author), Shuiqin Gong (Author), Tangli Xiao (Author), Daohai Zhang (Author), Yan Li (Author), Jiachuan Xiong (Author), Ke Yang (Author), Ting He (Author), Jinghong Zhao (Author), Yinghui Huang (Author)
• Format: Book
• Published: Frontiers Media S.A., 2022-11-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Acute kidney injury (AKI) is a common clinical syndrome with complex pathogenesis, characterized by a rapid decline in kidney function in the short term. Worse still, the incomplete recovery from AKI increases the risk of progression to chronic kidney disease (CKD). However, the pathogenesis and und...