Inhibition of A2A Adenosine Receptor Signaling in Cancer Cells Proliferation by the Novel Antagonist TP455

• Main Authors: Stefania Gessi (Author), Serena Bencivenni (Author), Enrica Battistello (Author), Fabrizio Vincenzi (Author), Vittoria Colotta (Author), Daniela Catarzi (Author), Flavia Varano (Author), Stefania Merighi (Author), Pier Andrea Borea (Author), Katia Varani (Author)
• Format: Book
• Published: Frontiers Media S.A., 2017-12-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Several evidences indicate that the ubiquitous nucleoside adenosine, acting through A1, A2A, A2B, and A3 receptor (AR) subtypes, plays crucial roles in tumor development. Adenosine has contrasting effects on cell proliferation depending on the engagement of different receptor subtypes in various tum...