Sulfonamidoboronic Acids as "Cross-Class" Inhibitors of an Expanded-Spectrum Class C Cephalosporinase, ADC-33, and a Class D Carbapenemase, OXA-24/40: Strategic Compound Design to Combat Resistance in <i>Acinetobacter baumannii</i>

• Main Authors: Maria Luisa Introvigne (Author), Trevor J. Beardsley (Author), Micah C. Fernando (Author), David A. Leonard (Author), Bradley J. Wallar (Author), Susan D. Rudin (Author), Magdalena A. Taracila (Author), Philip N. Rather (Author), Jennifer M. Colquhoun (Author), Shaina Song (Author), Francesco Fini (Author), Kristine M. Hujer (Author), Andrea M. Hujer (Author), Fabio Prati (Author), Rachel A. Powers (Author), Robert A. Bonomo (Author), Emilia Caselli (Author)
• Format: Book
• Published: MDPI AG, 2023-03-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

<i>Acinetobacter baumannii</i> is a Gram-negative organism listed as an urgent threat pathogen by the World Health Organization (WHO). Carbapenem-resistant <i>A. baumannii</i> (CRAB), especially, present therapeutic challenges due to complex mechanisms of resistance to <i&...