An ancestral role for the mitochondrial pyruvate carrier in glucose-stimulated insulin secretion

• Main Authors: Kyle S. McCommis (Author), Wesley T. Hodges (Author), Daniel K. Bricker (Author), Dona R. Wisidagama (Author), Vincent Compan (Author), Maria S. Remedi (Author), Carl S. Thummel (Author), Brian N. Finck (Author)
• Format: Book
• Published: Elsevier, 2016-08-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Objective: Transport of pyruvate into the mitochondrial matrix by the Mitochondrial Pyruvate Carrier (MPC) is an important and rate-limiting step in its metabolism. In pancreatic β-cells, mitochondrial pyruvate metabolism is thought to be important for glucose sensing and glucose-stimulated insulin...