Plasmatic exosomes from prostate cancer patients show increased carbonic anhydrase IX expression and activity and low pH

• Main Authors: Mariantonia Logozzi (Author), Davide Mizzoni (Author), Clemente Capasso (Author), Sonia Del Prete (Author), Rossella Di Raimo (Author), Mario Falchi (Author), Daniela F. Angelini (Author), Alessandro Sciarra (Author), Martina Maggi (Author), Claudiu T. Supuran (Author), Stefano Fais (Author)
• Format: Book
• Published: Taylor & Francis Group, 2020-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Acidity, hypoxia and increased release of exosomes are severe phenotypes of tumours. The regulation of pH in tumours involves the interaction of several proteins, including the carbonic anhydrases which catalyze the formation of bicarbonate and protons from carbon dioxide and water. Among CA isoform...