Regulation of p27 (Kip1) by Ubiquitin E3 Ligase RNF6

• Main Authors: Dhanraj Deshmukh (Author), Jin Xu (Author), Xi Yang (Author), Hermela Shimelis (Author), Shengyun Fang (Author), Yun Qiu (Author)
• Format: Book
• Published: MDPI AG, 2022-04-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

The cyclin-dependent kinase inhibitor p27 (Kip1) is an important regulator of the G1/S checkpoint. It is degraded by the SCF-SKP2 complex in late G1 thereby allowing cells to progress to the S phase. Here we investigated the role of the E3 ubiquitin ligase RNF6 (Ring Finger Protein 6) in cell cycle...